BCIP-Toluidine)5-Bromo-4-chloro-3-indolylphosphate-p-toluidine garam Cas:6578-06-9 99% Putih nganti coklat bubuk
| Nomer Katalog | XD90137 |
| Jeneng produk | BCIP-Toluidine) 5-Bromo-4-chloro-3-indolylphosphate-p-toluidine salt |
| CAS | 6578-06-9 |
| Formula Molekul | C8H5BrClNO4P·C7H10N |
| Bobot Molekul | 433.62 |
| Rincian panyimpenan | -15 nganti -20 °C |
| Kode Tarif Harmonisasi | 29339980 |
Spesifikasi Produk
| Penampilan | Wêdakakêna putih/coklat cahya |
| Assay | ≥ 99% |
| Titik lebur | 194-195ºC |
| Titik didih | 580,2 ° C ing 760 mmHg |
| Titik nyala | 304,7°C |
| Kelarutan | DMF: 20 mg/mL |
| Kelarutan | larut ing dimetilformamida, ora larut ing banyu. |
| Sensitivitas | Sensitif marang cahya, sensitif marang hawa, lan sensitif marang panas |
Aktivitas biologis: BCIP (BCIP p-toluidine salt; X-phosphate p-toluidine salt) minangka substrat kromogenik kanggo deteksi kolorimetri aktivitas fosfatase alkalin.
Racun Shiga (Stxs) diprodhuksi dening enterohemorrhagic Escherichia coli (EHEC), sing nyebabake infeksi manungsa kanthi asil sing asring fatal.Garis sel Vero, asalé saka ginjel monyet ijo Afrika, makili standar emas kanggo nemtokake efek sitotoksik saka Stxs.Senadyan panggunaan global, kawruh babagan struktur pas saka reseptor Stx glycosphingolipids (GSLs) lan perakitan ing rakit lipid kurang.Ing kene kita nampilake analisis struktural lengkap GSL reseptor Stx lan distribusi menyang membran tahan deterjen (DRM), sing disiapake saka sel Vero-B4 lan digunakake minangka setara rakit lipid.Kita ngenali globotriaosylceramide (Gb3Cer) lan globotetraosylceramide (Gb4Cer) minangka reseptor GSL kanggo subtipe Stx1a, Stx2a, lan Stx2e nggunakake deteksi overlay TLC sing digabung karo MS.Reseptor Stx sing ora umum, globopentaosylceramide (Gb5Cer, Galβ3GalNAcβ3Galα4Galβ4Glcβ1Cer), sing diakoni sacara khusus (saliyane Gb3Cer lan Gb4Cer) dening Stx2e, kanthi struktur kanthi lengkap.Lipoform saka GSL reseptor Stx ditemokake utamane ngemot ceramide ceramide sing kasusun saka sphingosine (d18: 1) lan C24: 0 / C24: 1 utawa C16: 0 asam lemak.Kajaba iku, kedadeyan bebarengan karo penanda rakit lipid, SM lan kolesterol, ing DRMs nyaranake asosiasi GSL karo mikrodomain membran.Panaliten iki nyedhiyakake dhasar kanggo njelajah luwih lanjut babagan pengaruh fungsional saka reseptor Stx sing ana gandhengane karo rakit lipid kanggo cedera sing dimediasi racun sel Vero-B4.
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