Produk

Limalas metallointercalators basis platinum(II) wis disintesis sing nggunakake ligan 1,10-fenantrolin (fen) sing diganti, kalebu 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-metil-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) lan dipyrido[3,2-d] :2',3'-f]quinoxaline (dpq), lan achiral ethylenediamine (en) lan ligan ancillary kiral 1S,2S-diaminocyclohexane (S,S-dach) lan 1R,2R-diaminocyclohexane (R,R-dach) .Sitotoksisitas ing garis sel leukemia murine L1210 ditemtokake nggunakake tes inhibisi pertumbuhan.Kompleks logam sing paling sitotoksik yaiku sing ngemot ligan tambahan S,S-dach lan ligan interkalasi 5-CH3-phen.Siji metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), nampilake sitotoksisitas 5-10 kali lipat dibandhingake karo agen klinis cisplatin.Saka eksperimen ngiket DNA katon ora ana bedane sing signifikan ing antarane kompleks logam, sing nuduhake yen afinitas pengikatan DNA utawa mode pengikatan/tambahan DNA sing dibentuk ora dadi siji-sijine penentu sitotoksisitas kulawarga basis platinum(II) iki. metallointercalators.