2-Amino-3-(4-hydroxyphenyl)propanoic acid Cas: 556-03-6 99% Kristal
Nomer Katalog | XD90297 |
Jeneng produk | 2-Amino-3-(4-hydroxyphenyl)propanoic acid |
CAS | 556-03-6 |
Formula Molekul | C9H11NO3 |
Bobot Molekul | 181.18854 |
Rincian panyimpenan | Suhu kamar |
Kode Tarif Harmonisasi | 29225000 |
Spesifikasi Produk
Assay | 99% |
Penampilan | Kristal |
Protein cerebral dopamine neurotrophic factor (CDNF) wis ditampilake kanggo nglindhungi jalur dopaminergik nigrostriatal nalika diwenehi infus intrastriatal ing model tikus lan tikus penyakit Parkinson (PD).Ing panliten iki, kita ngevaluasi efek neuroprotective CDNF sing dikirim karo vektor serotipe 2 virus adeno-associated (AAV) rekombinan ing model tikus 6-hydroxydopamine (6-OHDA) saka PD.Vektor AAV2 ngode CDNF, faktor neurotrofik turunan sel glial (GDNF), utawa protein fluoresensi ijo disuntikake menyang striatum tikus.Analisis ekspresi protein nuduhake yen vektor AAV2 kita kanthi efisien ngirim gen faktor neurotropik menyang otak lan nyebabake ekspresi protein sing tahan suwe.Rong minggu sawise injeksi vektor AAV2, 6-OHDA disuntikake menyang striatum tikus, nggawe degenerasi progresif sistem dopaminergik nigrostriatal.Perawatan karo AAV2-CDNF nyebabake nyuda rotasi ipsilateral sing disebabake amphetamine nalika mung nyedhiyakake proteksi parsial saka sel tyrosine hydroxylase (TH) -imunoreaktif ing substantia nigra pars compacta tikus lan serat TH-reaktif ing striatum.Asil saka panliten iki nyedhiyakake bukti tambahan yen CDNF bisa dianggep minangka perawatan potensial kanggo penyakit Parkinson